Levodopa for idiopathic restless legs syndrome : Evidence-based review
Identifieur interne : 003087 ( Main/Exploration ); précédent : 003086; suivant : 003088Levodopa for idiopathic restless legs syndrome : Evidence-based review
Auteurs : Cristiane Fiquene Conti [Brésil] ; Marcio Moyses De Oliveira [Brésil] ; Régis Bruni Andriolo [Brésil] ; Humberto Saconato [Brésil] ; Alvaro Nagib Atallah [Brésil] ; Juliana Spelta Valbuza [Brésil] ; Luciane Bizari Coin De Carvalho [Brésil] ; Gilmar Fernandes Do Prado [Brésil]Source :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi-randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night poly-somnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short-term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long-term treatment and the augmentation phenomenon in RLS. Further long-term randomized controlled trials using standard follow-up measurements as the International RLS Study Group Rating Scale are necessary.
Affiliations:
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Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sao Paulo Hospital Sleep Laboratory (Neuro -Sono /UNIFESP ), Federal University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fernandes Do Prado, Gilmar" sort="Fernandes Do Prado, Gilmar" uniqKey="Fernandes Do Prado G" first="Gilmar" last="Fernandes Do Prado">Gilmar Fernandes Do Prado</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 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type="wicri:Area/PascalFrancis/Checkpoint">001618</idno><idno type="wicri:doubleKey">0885-3185:2007:Fiquene Conti C:levodopa:for:idiopathic</idno><idno type="wicri:Area/Main/Merge">004208</idno><idno type="wicri:Area/Main/Curation">003087</idno><idno type="wicri:Area/Main/Exploration">003087</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Levodopa for idiopathic restless legs syndrome : Evidence-based review</title><author><name sortKey="Fiquene Conti, Cristiane" sort="Fiquene Conti, Cristiane" uniqKey="Fiquene Conti C" first="Cristiane" last="Fiquene Conti">Cristiane Fiquene Conti</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sao Paulo Hospital Sleep Laboratory (Neuro -Sono /UNIFESP ), Federal University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Moyses De Oliveira, Marcio" sort="Moyses De Oliveira, Marcio" uniqKey="Moyses De Oliveira M" first="Marcio" last="Moyses De Oliveira">Marcio Moyses De Oliveira</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sao Paulo Hospital Sleep Laboratory (Neuro -Sono /UNIFESP ), Federal University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Andriolo, Regis Bruni" sort="Andriolo, Regis Bruni" uniqKey="Andriolo R" first="Régis Bruni" last="Andriolo">Régis Bruni Andriolo</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Brazilian Cochrane Center, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Saconato, Humberto" sort="Saconato, Humberto" uniqKey="Saconato H" first="Humberto" last="Saconato">Humberto Saconato</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Brazilian Cochrane Center, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Nagib Atallah, Alvaro" sort="Nagib Atallah, Alvaro" uniqKey="Nagib Atallah A" first="Alvaro" last="Nagib Atallah">Alvaro Nagib Atallah</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Brazilian Cochrane Center, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Spelta Valbuza, Juliana" sort="Spelta Valbuza, Juliana" uniqKey="Spelta Valbuza J" first="Juliana" last="Spelta Valbuza">Juliana Spelta Valbuza</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sao Paulo Hospital Sleep Laboratory (Neuro -Sono /UNIFESP ), Federal University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Coin De Carvalho, Luciane Bizari" sort="Coin De Carvalho, Luciane Bizari" uniqKey="Coin De Carvalho L" first="Luciane Bizari" last="Coin De Carvalho">Luciane Bizari Coin De Carvalho</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sao Paulo Hospital Sleep Laboratory (Neuro -Sono /UNIFESP ), Federal University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Fernandes Do Prado, Gilmar" sort="Fernandes Do Prado, Gilmar" uniqKey="Fernandes Do Prado G" first="Gilmar" last="Fernandes Do Prado">Gilmar Fernandes Do Prado</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Emergency Medicine and Evidence Based Medicine, Federal University of Sao Paulo (UNIFESP)</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Sao Paulo Hospital Sleep Laboratory (Neuro -Sono /UNIFESP ), Federal University of Sao Paulo</s1><s2>Sao Paulo</s2><s3>BRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Brésil</country><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Idiopathic</term><term>Levodopa</term><term>Nervous system diseases</term><term>Restless legs syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pathologie du système nerveux</term><term>Syndrome des jambes sans repos</term><term>Lévodopa</term><term>Idiopathique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. The prevalence of RLS is estimated at 2.7 to 5% of adults and it is more common in women. The treatment of RLS with levodopa has been reported thus a systematic synthesis of evidence is necessary to evaluate the effectiveness and safety of levodopa for RLS. Systematic review of randomized or quasi-randomized, double blind trials on levodopa. Relief of restless legs symptoms marked on a validated scale, subjective sleep quality, sleep quality measured by night poly-somnography and actigraphy, quality of life measured by subjective measures, adverse events associated with the treatments. Nine eligible clinical trials were included. The subjective analyses of these studies showed contradictory results, although the objective analyses showed that treatment group had a statistically significant improvement of periodic leg movement (PLM) index, favoring the treatment group. The most commonly adverse event seen was gastrointestinal symptoms. The short-term treatment with levodopa was demonstrated effective and safety for PLM, but there was only few trials assessing long-term treatment and the augmentation phenomenon in RLS. Further long-term randomized controlled trials using standard follow-up measurements as the International RLS Study Group Rating Scale are necessary.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement></list><tree><country name="Brésil"><region name="État de São Paulo"><name sortKey="Fiquene Conti, Cristiane" sort="Fiquene Conti, Cristiane" uniqKey="Fiquene Conti C" first="Cristiane" last="Fiquene Conti">Cristiane Fiquene Conti</name></region><name sortKey="Andriolo, Regis Bruni" sort="Andriolo, Regis Bruni" uniqKey="Andriolo R" first="Régis Bruni" last="Andriolo">Régis Bruni Andriolo</name><name sortKey="Coin De Carvalho, Luciane Bizari" sort="Coin De Carvalho, Luciane Bizari" uniqKey="Coin De Carvalho L" first="Luciane Bizari" last="Coin De Carvalho">Luciane Bizari Coin De Carvalho</name><name sortKey="Coin De Carvalho, Luciane Bizari" sort="Coin De Carvalho, Luciane Bizari" uniqKey="Coin De Carvalho L" first="Luciane Bizari" last="Coin De Carvalho">Luciane Bizari Coin De Carvalho</name><name sortKey="Fernandes Do Prado, Gilmar" sort="Fernandes Do Prado, Gilmar" uniqKey="Fernandes Do Prado G" first="Gilmar" last="Fernandes Do Prado">Gilmar Fernandes Do Prado</name><name sortKey="Fernandes Do Prado, Gilmar" sort="Fernandes Do Prado, Gilmar" uniqKey="Fernandes Do Prado G" first="Gilmar" last="Fernandes Do Prado">Gilmar Fernandes Do Prado</name><name sortKey="Fiquene Conti, Cristiane" sort="Fiquene Conti, Cristiane" uniqKey="Fiquene Conti C" first="Cristiane" last="Fiquene Conti">Cristiane Fiquene Conti</name><name sortKey="Moyses De Oliveira, Marcio" sort="Moyses De Oliveira, Marcio" uniqKey="Moyses De Oliveira M" first="Marcio" last="Moyses De Oliveira">Marcio Moyses De Oliveira</name><name sortKey="Moyses De Oliveira, Marcio" sort="Moyses De Oliveira, Marcio" uniqKey="Moyses De Oliveira M" first="Marcio" last="Moyses De Oliveira">Marcio Moyses De Oliveira</name><name sortKey="Nagib Atallah, Alvaro" sort="Nagib Atallah, Alvaro" uniqKey="Nagib Atallah A" first="Alvaro" last="Nagib Atallah">Alvaro Nagib Atallah</name><name sortKey="Nagib Atallah, Alvaro" sort="Nagib Atallah, Alvaro" uniqKey="Nagib Atallah A" first="Alvaro" last="Nagib Atallah">Alvaro Nagib Atallah</name><name sortKey="Saconato, Humberto" sort="Saconato, Humberto" uniqKey="Saconato H" first="Humberto" last="Saconato">Humberto Saconato</name><name sortKey="Spelta Valbuza, Juliana" sort="Spelta Valbuza, Juliana" uniqKey="Spelta Valbuza J" first="Juliana" last="Spelta Valbuza">Juliana Spelta Valbuza</name><name sortKey="Spelta Valbuza, Juliana" sort="Spelta Valbuza, Juliana" uniqKey="Spelta Valbuza J" first="Juliana" last="Spelta Valbuza">Juliana Spelta Valbuza</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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